Inventors:
Barry M. Bernstein - Mequon WI, US
Rajeev M. Menon - Buffalo Grove IL, US
Amit Khatri - Waukegan IL, US
Sven Mensing - Mannheim, DE
Sandeep Dutta - Gurnee IL, US
Daniel E. Cohen - Wilmette IL, US
Thomas J. Podsadecki - Chicago IL, US
Scott C. Brun - Green Oaks IL, US
Walid M. Awni - Green Oaks IL, US
Emily O. Dumas - Libertyville IL, US
Cheri E. Klein - Northbrook IL, US
Assignee:
AbbVie Inc. - North Chicago IL
International Classification:
A61K 31/4965, A61K 31/33, A61K 31/505, A61K 31/47, A61K 31/415, A61K 31/40, A61K 31/675
US Classification:
51425505, 514183, 514269, 514314, 514397, 514309, 514394, 514422, 514 81
Abstract:
The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e. g. , ritonavir).