Scott A Jeffers
Plumbers at Brg St, Denver, CO
License number
Colorado 34577
Issued Date
Sep 27, 2013
Renew Date
Sep 27, 2013
Type
Plumbing Apprentice
Address
Address
2
1390 E Bridge St, Denver, CO 80601
Denver, CO
Denver, CO
Professional information
Pseudotyped Viruses And Methods For Their Use
US Patent:
2005011, May 26, 2005
Filed:
Mar 26, 2004
Appl. No.:
10/811353
Inventors:
Paul McCray - Iowa City IA, US
David Sanders - West Lafayette IN, US
Scott Jeffers - Aurora CO, US
Beverly Davidson - North Liberty IA, US
Patrick Sinn - Iowa City IA, US
David Sanders - West Lafayette IN, US
Scott Jeffers - Aurora CO, US
Beverly Davidson - North Liberty IA, US
Patrick Sinn - Iowa City IA, US
Assignee:
Purdue Research Foundation - West Lafayette IN
University of Iowa Research Foundation - Iowa City IA
University of Iowa Research Foundation - Iowa City IA
International Classification:
A61K048/00, A61K038/16
US Classification:
424093200, 514044000, 514008000
Abstract:
The invention provides a method to introduce a selected nucleic acid sequence into an airway epithelial cell that involves contacting the airway epithelial cell with a pseudotyped retrovirus that includes a glycoprotein in which a portion of an O-glycosylation region within the glycoprotein has been deleted and a retroviral capsid that includes the selected nucleic acid sequence. The invention also provides a method to reduce or eliminate the symptoms of cystic fibrosis in a mammal that involves contacting an airway epithelial cell of the mammal with a pseudotyped retrovirus that includes a glycoprotein in which a portion of an O-glycosylation region within the glycoprotein has been deleted and a retroviral capsid that includes a nucleic acid sequence that encodes a cystic fibrosis transmembrane regulator protein.
Pseudotyped Retrovirus With Modified Ebola Glycoprotein
US Patent:
7981656, Jul 19, 2011
Filed:
Jun 4, 2003
Appl. No.:
10/516578
Inventors:
David A. Sanders - West Lafayette IN, US
Scott A. Jeffers - Aurora CO, US
Anthony Sanchez - Lilburn GA, US
Scott A. Jeffers - Aurora CO, US
Anthony Sanchez - Lilburn GA, US
Assignee:
Purdue Research Foundation - West Lafayette IN
Centers for Disease Control and Prevention - Atlanta GA
Centers for Disease Control and Prevention - Atlanta GA
International Classification:
C12N 7/00, C07H 21/02
US Classification:
4352351, 977802, 977803, 536 231
Abstract:
Pseudotyped retroviruses having viral glycoproteins with modified O glycosylation regions are provided. Also provided are methods for making the pseudotyped retroviruses of the present invention and for using the pseudotyped retroviruses for transduction of target cells. Cells for stably producing the pseudotyped retroviruses or the present invention are also provided.