Inventors:
Massimo Cristofanilli - Pearland TX, US
Savitri Krishnamurthy - Houston TX, US
Kerstin Menander - Bellaire TX, US
Gabriel Hortobagyi - Bellaire TX, US
International Classification:
A61K 48/00
Abstract:
A method of stimulating an immune response to a tumor in an immunocompetent subject by administering a p53 expression construct to a tumor. The construct expresses p53 in tumor cells in an amount sufficient to stimulate an immune response against the tumor. Both viral and non-viral delivery systems are contemplated. The method can be combined with chemotherapy agents as well as with other cancer therapies.