Inventors:
Thomas M. Barnes - Cambridge MA, US
Michael M. Schmidt - Cambridge MA, US
Bracken M. King - Cambridge MA, US
K. Christopher Garcia - Menlo Park CA, US
Sashank Reddy - Boston MA, US
Gregory James Sieczkiewicz - Hopkinton MA, US
Lauren K. Ely - Palo Alto CA, US
Assignee:
Eleven Biotherapeutics, Inc. - Cambridge MA
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61K 38/20, C12P 21/02, C12N 5/10, C12N 1/21, A61P 29/00, C12N 1/19, C07K 14/54, C07K 16/24, C07H 21/04, A61P 37/02, A61K 39/395, C12N 1/15
US Classification:
424 852, 4241391, 435 691, 435 6952, 435 696, 435325, 435348, 435366, 435419, 43525231, 43525233, 43525234, 43525411, 4352542, 43525421, 43525423, 530351, 5303879, 536 234, 536 235, 536 2353
Abstract:
Binding proteins, including non-naturally occurring and recombinantly modified proteins that bind to an IL-17R and including proteins having a mutated IL-17 cytokine sequence, methods of making such molecules and methods of using such molecules as therapeutic, prophylactic and diagnostic agents are provided.