DR. SARAH P THAYER, MD PHD
Radiology at Parkman St, Boston, MA
License number
Massachusetts 203874
Category
Radiology
Type
Surgery
Address
Address
15 Parkman St, Boston, MA 02114
Phone
(617) 726-0624
(617) 726-0630 (Fax)
(617) 726-0630 (Fax)
Personal information
See more information about SARAH P THAYER at radaris.comName
Address
Phone
475 New Salem Rd, Wendell, MA 01379
11 Lakeview Rd, Winchester, MA 01890
16 W Main St #B, New Salem, MA 01355
14 Depot Rd, Hatfield, MA 01038
16 Main St, New Salem, MA 01355
Organization information
See more information about SARAH P THAYER at bizstanding.comPsychiatry Department - Sarah P Thayer MD
15 Parkman St #WACC460, Boston, MA 02114
Categories:
General Surgeons
Phone:
(617) 724-6980 (Phone)
Professional information
Sarah P Thayer, Boston MA
Specialties:
Surgery, Surgery of the Hand, Surgical Oncology, Gastroenterology, Surgery of the Hand, Orthopaedic Surgery of the Hand
Work:
Massachusetts General Hospital
15 Parkman St, Boston, MA 02114 Massachusetts General Hospital
55 Fruit St, Boston, MA 02114
15 Parkman St, Boston, MA 02114 Massachusetts General Hospital
55 Fruit St, Boston, MA 02114
Education:
University of Virginia (1991)
Method For Inducing Beta Cell Neogenesis From Epithelial Cells
US Patent:
2009030, Dec 10, 2009
Filed:
May 18, 2009
Appl. No.:
12/467707
Inventors:
Sarah P. Thayer - Boston MA, US
Jennifer LaFemina Fowler - Jamaica Plain MA, US
Andrew L. Warshaw - Boston MA, US
Carlos Fernandez-del Castillo - Newton MA, US
Jennifer LaFemina Fowler - Jamaica Plain MA, US
Andrew L. Warshaw - Boston MA, US
Carlos Fernandez-del Castillo - Newton MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 38/16, C12N 5/06
US Classification:
514 12, 435375
Abstract:
The invention provides a method of inducing β-cell neogenesis from epithelial cells. The method includes the step of exposing epithelial cells that have a disrupted G1-S cell cycle transition to a hedgehog protein in an amount effective to stimulate β-cell neogenesis from the epithelial cells. Cells resulting from the method are insulin-positive and express pancreatic progenitor cell markers including Pdx-1 and ngn3. β-cell population expansion is observed when the method is carried out in either in vitro or in vivo settings.