SARAH LOUISE GRAY
Veterinary in Saint Paul, MN
License number
Pennsylvania BV011611
Category
Veterinary Medicine
Type
Veterinarian
Address
Address
2
Saint Paul, MN 55102
Pennsylvania
Pennsylvania
Professional information
Antifungal Agents
US Patent:
8222255, Jul 17, 2012
Filed:
Sep 25, 2008
Appl. No.:
12/680472
Inventors:
James M. Balkovec - Martinsville NJ, US
Phieng Siliphaivanh - Newtown MA, US
Frances A. Bouffard - Scotch Plains NJ, US
Michael R. Peel - Chapel Hill NC, US
Weiming Fan - Chapel Hill NC, US
Ahmed Mamai - Raleigh NC, US
Sarah Dimick Gray - Eagan MN, US
Phieng Siliphaivanh - Newtown MA, US
Frances A. Bouffard - Scotch Plains NJ, US
Michael R. Peel - Chapel Hill NC, US
Weiming Fan - Chapel Hill NC, US
Ahmed Mamai - Raleigh NC, US
Sarah Dimick Gray - Eagan MN, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
Scynexis, Inc. - Research Triangle Park NC
Scynexis, Inc. - Research Triangle Park NC
International Classification:
C07D 311/78, C07D 405/02, A61K 31/352, A61K 31/4025, A61K 31/4433, A61K 31/453, A61K 31/496, A61K 31/506, A61K 31/5355
US Classification:
51425411, 514422, 514378, 514297, 514453, 514316, 514320, 549382, 548525, 548243, 5483114, 546196, 546187, 544150, 544375
Abstract:
Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.