Inventors:
C. Frank Bennett - Carlsbad CA, US
Susan M. Freier - San Diego CA, US
Sarah Greenlee - San Diego CA, US
Eric E. Swayze - Encinitas CA, US
Assignee:
Isis Pharmaceuticals Inc. - Carlsbad CA
International Classification:
C12N 15/113, A61K 31/7088, A61P 25/28, A61P 25/00, A61P 25/16, A61P 11/00, A61P 1/16, A61P 11/06, A61P 29/00, A61P 27/12, A61P 3/10, A61P 9/10, A61P 27/02, A61P 9/12, A61P 3/04, A61P 25/24, A61P 35/00, C12N 5/07
US Classification:
514 44 A, 536 245, 435375
Abstract:
Disclosed herein are antisense compounds and methods for selectively of reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative, such as Huntington's Disease (HD).