SARAH ELIZABETH SMITH, RN, SANE-A
Nursing at 10 St, Indianapolis, IN

2007007, Mar 29, 2007

Feb 18, 2005

10/597835

Serge Boulet - Fishers IN, US
Anette Johansson - Indianapolis IN, US
Sarah Smith - Indianapolis IN, US

Eli Lilly and Company - Indianapolis IN

A61K 31/5375, A61K 31/445, A61K 31/40, A61K 31/137, C07D 211/06

514237800, 514317000, 514408000, 514651000, 514649000, 548561000, 546205000, 546229000, 544158000, 544162000, 564341000, 564349000

The present invention relates to inhibitors of serotonin and/or norepinephrine reuptake and specifically provides compounds of formula (I): wherein A is selected from —O— and —S—; X is selected from C-Calkyl, C-Calkenyl, and C-Ccycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from phenyl, pyrrolidinyl, piperidinyl, morpholinyl, halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, —CF, —CN and —CONH; Y is selected from (a), (b), (c), (d), (e), (f) where R, Rand Rare independently selected from hydrogen, halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; Rand Rare independently selected from halo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; Ris selected from chloro, bromo, iodo, C-Calkyl, C-Calkoxy, C-Calkyl-S(O)— where n is 0, 1 or 2, nitro, acetyl, —CF, —SCFand cyano; Rand Rare each independently hydrogen or C-Calkyl; or pharmaceutically acceptable salts thereof; or compositions thereof and methods of using the same.