Inventors:
Richard Bucala - Cos Cob CT, US
Lin Leng - New York NY, US
Sarah Doernberg - San Francisco CA, US
International Classification:
A61K 38/22, C12Q 1/68, C07H 21/04, C40B 40/06, A61K 31/7088, A61K 39/395, G01N 33/53, A61P 7/06, A61P 31/00
US Classification:
4241721, 435 6, 536 2432, 506 16, 514 44 A, 514 8, 436501
Abstract:
The present invention relates to methods and compositions for selecting a subject for treatment with an agonist or antagonist of macrophage migration inhibitory factor (MIF), identifying a subject at risk for developing a disease associated with high or low MIF expression, predicting the severity of a disease associated with high or low MIF expression in a subject, and for predicting whether a subject is susceptible to a disease associated with high or low MIF expression. The invention also provides novel methods of diagnosing a patient for a disease associated with high or low MIF expression. Also provided are methods for treating a subject having a disease or disorder associated with high or low MIF expression.