SARA M BODNER
Medical Practice in New Haven, CT
License number
Pennsylvania MT180775
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
2
New Haven, CT 06513
Pennsylvania
Pennsylvania
Personal information
See more information about SARA M BODNER at radaris.comName
Address
Phone
New Kensington, PA
140 Mill St, East Haven, CT 06512
920 Quinnipiac Ave, New Haven, CT 06513
1119 Meadow Dr, Blue Bell, PA 19422
Professional information
See more information about SARA M BODNER at trustoria.com
Cyclin D Binding Factor, And Uses Thereof
Cyclin D Binding Factor, And Uses Thereof
US Patent:
6673902, Jan 6, 2004
Filed:
Jun 27, 2001
Appl. No.:
09/892398
Inventors:
Charles J. Sherr - Memphis TN
Hiroshi Hirai - Ibaraki, JP
Sara M. Bodner - New Haven CT
Kazushi Inoue - Memphis TN
Hiroshi Hirai - Ibaraki, JP
Sara M. Bodner - New Haven CT
Kazushi Inoue - Memphis TN
Assignee:
St. Jude Childrens Research Hospital - Memphis TN
International Classification:
C07K 1600
US Classification:
5303871, 5303879
Abstract:
The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.
Cyclin D Binding Factor, And Uses Thereof
Cyclin D Binding Factor, And Uses Thereof
US Patent:
6303772, Oct 16, 2001
Filed:
Mar 29, 1999
Appl. No.:
9/280590
Inventors:
Charles J. Sherr - Memphis TN
Hiroshi Hirai - Ibaraki, JP
Sara M. Bodner - New Haven CT
Kazushi Inoue - Memphis TN
Hiroshi Hirai - Ibaraki, JP
Sara M. Bodner - New Haven CT
Kazushi Inoue - Memphis TN
Assignee:
St. Jude Children's Research Hospital - Memphis TN
International Classification:
C07K 122, C07K 1439, C07K 14435, C07K 1614
US Classification:
536 237
Abstract:
The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.