Inventors:
John C. Cambier - Denver CO, US
Yosef Refaeli - Denver CO, US
Sara Ann Johnson - Denver CO, US
Brian Curtis Turner - Denver CO, US
Assignee:
TAIGA BIOTECHNOLOGIES, INC. - Aurora CO
International Classification:
C12N 5/02, C12N 5/0789
Abstract:
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.