Inventors:
Timothy F. Murphy - Amherst NY
Sanjay Sethi - Williamsville NY
Assignee:
The Research Foundation of State University of New York - Amherst NY
International Classification:
C12P 2106, C12P 2104, C12N 1500, C07H 2104
Abstract:
Nucleotide sequences, derived from Moraxella catarrhalis, which encode one or more epitopes of outer membrane protein B1 are disclosed. Recombinant B1 protein or B1 peptides may be produce by culturing in a medium a host cell genetically engineered to contain and express a nucleotide sequence according to the present invention, and recovering the recombinant protein or peptide from the cultured host cell or culture medium. The nucleotide sequence of the present invention can also be used in molecular diagnostic assays for detecting M. catarrhalis genetic material, and in antigenic compositions for producing B1-specific amino acids.