Inventors:
Partha S. Ray - Los Angeles IL, US
Sanjay Bagaria - Jacksonville FL, US
Xiaojiang Cui - Pearland TX, US
Jinhua Wang - Los Angeles CA, US
International Classification:
A61K 9/127, C12Q 1/68, A61K 31/713, A61K 31/7088, A61K 39/395, A61K 31/138, A61P 35/00
US Classification:
424450, 435 61, 435 612, 514 44 A, 4241741, 4241331, 514648
Abstract:
In one embodiment, a method of theranostic classification of a breast cancer tumor is provided, comprising obtaining a breast cancer tumor sample from a subject, detecting an expression level of FOXC1, comparing the expression level of FOXC1 to a predetermined cutoff level, and classifying the breast cancer tumor sample as belonging to a theranostic basal-like breast cancer tumor subtype or a theranostic hybrid basal-like breast cancer tumor subtype when the expression level of FOXC1 is higher than the predetermined cutoff level. In other embodiments, methods for predicting a prognosis of a basal-like breast cancer and methods of treating a basal-like breast cancer are provided,