Inventors:
Sanford Shattil - La Jolla CA, US
Glen Nemerow - Encinitas CA, US
Takaaki Hato - Imabari, JP
Dwayne Stupack - San Diego CA, US
Nisar Pampori - Frederick MD, US
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C12Q001/70, G01N033/53, G01N033/567, G01N033/574, A61K039/395, A61K048/00
US Classification:
435/005000, 435/007200, 424/143100, 435/007230, 424/093200
Abstract:
The present invention provides ligands which can selectively bind to activated integrin. A novel monovalent ligand-mimetic (WOW-1 Fab) which includes a single integrin-binding domain from multivalent adenovirus penton base is provided. Further, the present invention describes particular compositions of activated -specific ligands, such as an antibody which immunoreacts preferentially with activated integrin. The invention also describes methods using an activated -specific ligand for diagnostic detection of activated integrin in tissues and for the targeted delivery of therapeutic agents to tissues containing activated integrin.