DR. SANDRA READING CHAPLAN, M.D.
Anesthesiologist Assistant at Merryfield Row, San Diego, CA
License number
California G55483
Category
Osteopathic Medicine
Type
Anesthesiology
Address
Address
3210 Merryfield Row, San Diego, CA 92121
Phone
(858) 784-3280
Personal information
See more information about SANDRA READING CHAPLAN at radaris.comName
Address
Phone
4421 Cape May Ave, San Diego, CA 92107
4523 Muir Ave, San Diego, CA 92107
Professional information
See more information about SANDRA READING CHAPLAN at trustoria.com
Sr Director, Clinical Development At Janssen Research &Amp; Development, Llc
Sr Director, Clinical Development At Janssen Research &Amp; Development, Llc
Position:
Sr Director Clinical Research MD at Janssen Research & Development, LLC
Location:
Greater San Diego Area
Industry:
Pharmaceuticals
Work:
Janssen Research & Development, LLC
since Dec 2010
-
Sr Director Clinical Research MD
Johnson & Johnson Pharmaceutical Research & Development
Jan 2010 - Dec 2010
-
Sr Director, Neuroscience External Innovation
Johnson & Johnson Pharmaceutical Research & Development
2000 - Jan 2010
-
Team Leader
University of California, San Diego
1992 - 2000
-
Anesthesiology Department
Pittsburgh Anesthesia Associates
1990 - 1992
-
Director, Pain Services
Education:
Stanford University School of Medicine 1986 - 1990
Cornell University 1980 - 1984
MD, Medicine Yale University 1977
BA, Literature Columbia University in the City of New York
Wesleyan University
Cornell University 1980 - 1984
MD, Medicine Yale University 1977
BA, Literature Columbia University in the City of New York
Wesleyan University
Skills:
Neuroscience, Clinical Development, Molecular Biology, Drug Discovery, Pain, Clinical Trials, Pain Management, Drug Development, Biotechnology, Clinical Research, Lifesciences, Infectious Diseases, Cancer, In Vivo, CRO, Translational Medicine, Oncology, Pharmaceutical Industry, Immunology, Medical Writing, Medical Affairs
Dr. Sandra R Chaplan, San Diego CA - MD (Doctor of Medicine)
Dr. Sandra R Chaplan, San Diego CA - MD (Doctor of Medicine)
Specialties:
Anesthesiology
Address:
3210 Merryfield Row, San Diego 92121
(858) 784-3280 (Phone)
(858) 784-3280 (Phone)
Certifications:
Anesthesiology, 1990
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Weill Cornell Medical College
Graduated: 1984
University Of Washington
Stanford U Med Ctr
Stanford University
Weill Cornell Medical College
Graduated: 1984
University Of Washington
Stanford U Med Ctr
Stanford University
Sandra Reading Chaplan, San Diego CA
Sandra Reading Chaplan, San Diego CA
Specialties:
Anesthesiologist
Address:
3210 Merryfield Row, San Diego, CA 92121
Assay Systems And Methods For Detecting Molecules That Interact With Sk2 Channels
Assay Systems And Methods For Detecting Molecules That Interact With Sk2 Channels
US Patent:
2008026, Oct 30, 2008
Filed:
Apr 25, 2007
Appl. No.:
11/739789
Inventors:
Edward Kaftan - Pennington NJ, US
Adrienne Elizabeth Dubin - San Diego CA, US
Sandra R. Chaplan - San Diego CA, US
Adrienne Elizabeth Dubin - San Diego CA, US
Sandra R. Chaplan - San Diego CA, US
International Classification:
C12Q 1/68, G01N 33/53
US Classification:
435 6, 435 71
Abstract:
The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.
Assay Systems And Methods For Detecting Molecules That Interact With Sk2 Channels
Assay Systems And Methods For Detecting Molecules That Interact With Sk2 Channels
US Patent:
2005025, Nov 10, 2005
Filed:
Oct 28, 2004
Appl. No.:
10/975798
Inventors:
Edward Kaftan - Pennington NJ, US
Adrienne Dubin - San Diego CA, US
Sandra Chaplan - San Diego CA, US
Adrienne Dubin - San Diego CA, US
Sandra Chaplan - San Diego CA, US
International Classification:
C12Q001/00, C12Q001/68
US Classification:
435004000, 435006000
Abstract:
The invention provides methods including steps of: providing cells capable of expressing SK2; contacting the cells with a test molecule; obtaining information indicative of cellular SK2 expression to obtain an SK2 Expression Value; comparing the SK2 Expression Value with a control SK2 Expression Value; and identifying a test molecule that causes the cells to display an SK2 Expression Value that is different from the control SK2 Expression Value. Also provided are methods including steps of: providing a sample comprising an SK2 channel; contacting the sample with a test molecule; obtaining information indicative of SK2 channel activity in the sample to obtain an SK2 Channel Activity Value; comparing the SK2 Channel Activity Value with a control Channel Activity Value; and identifying a test molecule that causes the SK2 Channel Activity Value to be different from the control Channel Activity Value. Methods of identifying a molecule useful for treating neuropathic pain are also described.
Method For Identifying Modulators Of Naion Channels
Method For Identifying Modulators Of Naion Channels
US Patent:
7195879, Mar 27, 2007
Filed:
Apr 12, 2002
Appl. No.:
10/121759
Inventors:
Adrienne Dubin - San Diego CA, US
Sandra Chaplan - San Diego CA, US
Sean Brown - Encinitas CA, US
Edward Kaftan - Mount Prospect IL, US
Sandra Chaplan - San Diego CA, US
Sean Brown - Encinitas CA, US
Edward Kaftan - Mount Prospect IL, US
Assignee:
Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ
International Classification:
G01N 33/53, C12N 5/00, C07D 239/00, C07C 69/00
US Classification:
435 71, 435375, 544247, 560 3
Abstract:
The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Naexpression is either Na1. 3 in IMR-32 cells exposed to retinoic acid or Na1. 7 in cells grown under non-differentiating conditions. The cells of the present invention are useful for the discovery of new compounds that modulate the function of either Na1. 3 and/or Na1. 7.
Compositions And Methods For Treating Pain
Compositions And Methods For Treating Pain
US Patent:
5849737, Dec 15, 1998
Filed:
Apr 14, 1995
Appl. No.:
8/422377
Inventors:
Sandra Reading Chaplan - San Diego CA
Flemming Winther Bach - Aarhus, DK
Tony Lee Yaksh - San Diego CA
Flemming Winther Bach - Aarhus, DK
Tony Lee Yaksh - San Diego CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 31535, A61K 3116
US Classification:
5142388
Abstract:
Compositions and methods for alleviating pain (in particular, neuropathic pain) in a mammalian patient, wherein an effective amount of a physiologically-acceptable salt of a compound of the general formula ##STR1## wherein each of R. sup. 1, R. sup. 2 and R. sup. 3 is independently selected from the group consisting of hydrogen, hydroxyl, acyl, alkoxyl, alkyl, aryl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl, alkoxyaryl and NR. sup. 8 R. sup. 9, in which each of R. sup. 8 and R. sup. 9 is independently selected from the group consisting of hydrogen, alkyl, aryl, acyl, alkylaryl, arylalkyl, hydroxyalkyl, hydroxyaryl, alkoxyalkyl and alkoxyaryl, with the proviso that at least one of R. sup. 1, R. sup. 2 and R. sup. 3 is hydroxyl;
each of R. sup. 4 and R. sup. 5 is independently selected from the group consisting of hydrogen, halogen and lower alkyl;
A is --C(. dbd.
Method Of Producing Analgesia
Method Of Producing Analgesia
US Patent:
6166085, Dec 26, 2000
Filed:
Sep 13, 1996
Appl. No.:
8/713339
Inventors:
Sandra Reading Chaplan - San Diego CA
Flemming Winther Bach - Aarhus, DK
Tony Lee Yaksh - San Diego CA
Flemming Winther Bach - Aarhus, DK
Tony Lee Yaksh - San Diego CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3152
US Classification:
514626
Abstract:
The invention relates to methods of producing analgesia, particularly in the treatment-of-acute and persistent pain and neuropathic pain. The compound 2(ethylamino)-N-(3-hydroxy-2,6-dimethylphenyl) acetamide, or 3-hydroxymonoethylglycinexylidide (3-hydroxy MEGX), is shown to provide analgesia in settings of acute, persistent and neuropathic pain.
Treating Pain By Targeting Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channels
Treating Pain By Targeting Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channels
US Patent:
2003002, Jan 30, 2003
Filed:
May 30, 2002
Appl. No.:
10/158711
Inventors:
Sandra Chaplan - San Diego CA, US
Adrienne Dubin - San Diego CA, US
Hong-Qing Guo - San Diego CA, US
Doo Lee - Cardiff CA, US
Changlu Liu - San Diego CA, US
Lin Luo - La Jolla CA, US
Sean Brown - Encinitas CA, US
Adrienne Dubin - San Diego CA, US
Hong-Qing Guo - San Diego CA, US
Doo Lee - Cardiff CA, US
Changlu Liu - San Diego CA, US
Lin Luo - La Jolla CA, US
Sean Brown - Encinitas CA, US
International Classification:
A61K031/00
US Classification:
514/001000
Abstract:
Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Iand modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.
Treating Pain By Targeting Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channels
Treating Pain By Targeting Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channels
US Patent:
2003002, Jan 30, 2003
Filed:
May 30, 2002
Appl. No.:
10/158684
Inventors:
Sandra Chaplan - San Diego CA, US
Adrienne Dubin - San Diego CA, US
Doo Lee - Cardiff CA, US
Changlu Liu - San Diego CA, US
Adrienne Dubin - San Diego CA, US
Doo Lee - Cardiff CA, US
Changlu Liu - San Diego CA, US
International Classification:
A61K031/00
US Classification:
514/001000
Abstract:
Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Iand modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.