Inventors:
Satish Singh - Portage MI, US
Lisa Adams - Mattawan MI, US
Paramita Bandyopadhyay - Portage MI, US
Syed Hasan - Portage MI, US
Leslie Hawley - Kalamazoo MI, US
Sandra Sims - Portage MI, US
International Classification:
A61K031/724, A61K031/553, A61K031/554, A61K031/541, A61K031/5377, A61K031/427, A61K031/42
US Classification:
514/058000, 514/211150, 514/227800, 514/236800, 514/365000, 514/376000
Abstract:
There is provided a pharmaceutical preservative free composition suitable for topical administration to an eye, the composition comprising (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug-in solution at such a drug concentration. The composition is particularly useful for the treatment and/or prevention of eye infections due to gram positive bacteria.