DR. SAMUEL LEONARD STANLEY, MD
Osteopathic Medicine at Euclid Ave, Saint Louis, MO
License number
Missouri R5D11
Category
Osteopathic Medicine
Type
Infectious Disease
Address
Address
660 S Euclid Ave, Saint Louis, MO 63110
Phone
(314) 747-3000
(314) 747-4511 (Fax)
(314) 747-4511 (Fax)
Personal information
See more information about SAMUEL LEONARD STANLEY at radaris.comName
Address
Phone
Rr 1 BOX 287 # H, Marble Hill, MO 63764
3131 Woodland Ave, Joplin, MO 64804
1843 Kansas Ave, Kansas City, MO 64127
9036 103Rd St, Kansas City, MO 64157
8170 Oakley Ave, Kansas City, MO 64119
Professional information
Vice Chancellor For Research At Washington University
Location:
Greater St. Louis Area
Industry:
Biotechnology
Method Of Screening Anti-Amebic Agents With An E. Coli Mutant Having A Deleted Adhe Gene Complemented By The E. Histolytica Ehadh2 Gene
US Patent:
5807700, Sep 15, 1998
Filed:
Nov 27, 1995
Appl. No.:
8/562969
Inventors:
Samuel L. Stanley - Ladue MO
Assignee:
Washington University - St. Louis MO
International Classification:
C12Q 118
US Classification:
435 32
Abstract:
There is disclosed an assay method of screening and identification of anti-amebic drugs which utilizes the ability to inhibit anaerobic growth of a novel bacterial mutant that expresses the EhADH2 gene and which bypasses the conventional need for a parasitic culture. The novel mutant, designated E. coli/EhADH2, is cultured under anaerobic conditions, a predetermined or known quantity of the agent to be tested or target compound is combined with the cell culture, and the combination is then monitored to determine the inhibitory effect upon the anaerobic growth of the E. coli/EhADH2 cell mutant.
Amebic Glycoconjugate And Monoclonal Antibody
US Patent:
5275935, Jan 4, 1994
Filed:
Sep 10, 1992
Appl. No.:
7/943095
Inventors:
Samuel L. Stanley - Ladue MO
Ellen Li - Ladue MO
Ellen Li - Ladue MO
Assignee:
Washington University - St. Louis MO
International Classification:
G01N 33569, C07K 1528, C12P 2108, C12N 512
US Classification:
435 722
Abstract:
An amebic glycoconjugate is disclosed that is recognized by an Entamoeba histolytica specific monoclonal antibody The glycoconjugate is isolated from the lysates of E. histolytica trophozoites, it is phosphorylated, lipid-containing, glycosylated, migrates as a polydisperse band on SDS-PAGE between about 65-200 kDa and is specifically recognized by monoclonal antibody CC 8. 6, ATCC HB 11104.