Inventors:
Samuel Bernal - Woodland Hills CA, US
Douglas Burkett - Gilbert AZ, US
Ralph Green - Scottsdale AZ, US
Seth Rose - Tempe AZ, US
International Classification:
A61K039/395, G01N033/574
Abstract:
A diagnostic method for detecting cancerous epithelial cells by selectively marking the mitochondria of the cancer cells, by delivering to the epithelium a cationic supravital mitochondrial marking agent. Selective killing of cancerous epithelial cells in the presence of normal cells is effected by delivering a cationic supravital mitochondrial marking agent to epithelial cancer cells. The killing agent can also comprise the reaction product of the marking agent and a cancer chemotherapeutic drug or in admixture