Inventors:
Mark A. Exley - Chestnut Hill MA, US
Samuel B. Wilson - Lexington MA, US
Steven P. Balk - Needham MA, US
Assignee:
Beth Israel Deaconess Medical Center, Inc. - Boston MA
Dana-Farber Cancer Institute - Boston MA
The General Hospital Corporation - Boston MA
International Classification:
C12P 21/08
Abstract:
The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and JαQ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.