SAMUEL A MILLER
Broker in Brookline, MA
License number
Massachusetts 9525586
Issued Date
Dec 19, 2012
Expiration Date
Oct 13, 2015
Type
Salesperson
Address
Address
Brookline, MA 02445
Professional information
Salmonella Vectors Encoding Truncated Pag Fusion Protein, Method Of Making, And Uses Thereof
US Patent:
5733760, Mar 31, 1998
Filed:
Aug 5, 1994
Appl. No.:
8/286767
Inventors:
Yichen Lu - Cambridge MA
Samuel I. Miller - Brookline MA
Kevin Killeen - Milton MA
Samuel I. Miller - Brookline MA
Kevin Killeen - Milton MA
Assignee:
Virus Research Institute - Cambridge MA
The General Hospital Corporation - Boston MA
The General Hospital Corporation - Boston MA
International Classification:
C12N 1500, C12N 1563, A61K 3921, A61K 39112
US Classification:
4351723
Abstract:
A modified Salmonella, wherein the wild type pag gene such as pagC has been replaced by a gene encoding a truncated pag gene such as pagC gene fused to a heterologous DNA segment, is disclosed. This modification significantly attenuates the virulence of the Salmonella. In addition, immune reaction to the portion of the fusion protein encoded by the heterologous gene can be generated. Uses of the vector, including its use in a drug screen are also disclosed.
Salmonella Virulence Genes
US Patent:
5599537, Feb 4, 1997
Filed:
Jul 9, 1993
Appl. No.:
8/090526
Inventors:
Samuel I. Miller - Brookline MA
John J. Mekalanos - Cambridge MA
John J. Mekalanos - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 39112, C12N 120, C12N 121
US Classification:
424 932
Abstract:
A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
Antibiotic Cryptdin Peptides And Methods Of Their Use
US Patent:
5422424, Jun 6, 1995
Filed:
Aug 14, 1992
Appl. No.:
7/930649
Inventors:
Michael E. Selsted - Irvine CA
Andre J. Ouellette - Lynn MA
Samuel I. Miller - Brookline MA
Andre J. Ouellette - Lynn MA
Samuel I. Miller - Brookline MA
Assignee:
The Regents of the University of California - Oakland CA
The Shriner's Hospital for Crippled Children - Tampa FL
The General Hospital Corporation - Boston MA
The Shriner's Hospital for Crippled Children - Tampa FL
The General Hospital Corporation - Boston MA
International Classification:
C07K 710
US Classification:
530324
Abstract:
The present invention provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:
X. sub. 1 -C-X. sub. 2 -C-R-X. sub. 3 -C-X. sub. 4 -E-X. sub. 5 -G-X. sub. 6 -C-X. sub. 7 -C-C-X. sub. 8
wherein X. sub. 1 is 3-6 amino acids; X. sub. 2 is one amino acid; X. sub. 3 is 2 or 3 amino acids; X. sub. 4 is three amino acids; X. sub. 5 is three amino acids; X. sub. 6 is one amino acid; X. sub. 7 is 6 to 10 amino acids; and X. sub. 8 is 0 to 7 amino acids.
The invention further provides substantially purified cryptdin peptides having a consensus amino acid sequence as follows:
X. sub. 1 -L-X. sub. 2 -C-Y-C-R-X. sub. 3 -C-K-X. sub. 4 -E-R-X. sub. 5 -G-T-C-X. sub. 6 -C-C-X. sub. 7
wherein X. sub.
Salmonella Virulence Genes
US Patent:
5674736, Oct 7, 1997
Filed:
Jun 7, 1995
Appl. No.:
8/486719
Inventors:
Samuel I. Miller - Brookline MA
John J. Mekalanos - Cambridge MA
John J. Mekalanos - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 120, C12N 136, C12N 1501, A61K 39112
US Classification:
4352523
Abstract:
A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
Salmonella Virulence Genes
US Patent:
6010901, Jan 4, 2000
Filed:
Jun 7, 1995
Appl. No.:
8/475749
Inventors:
Samuel I. Miller - Brookline MA
John J. Mekalanos - Cambridge MA
John J. Mekalanos - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 1574, C07H 2104
US Classification:
4353201
Abstract:
A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
Salmonella Virulence Genes
US Patent:
5674724, Oct 7, 1997
Filed:
Jun 7, 1995
Appl. No.:
8/486715
Inventors:
Samuel I. Miller - Brookline MA
John J. Mekalanos - Cambridge MA
John J. Mekalanos - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 1501, C12N 136, C12N 120, C12P 2102
US Classification:
4351723
Abstract:
A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
Salmonella Virulence Genes
US Patent:
5731196, Mar 24, 1998
Filed:
Oct 6, 1995
Appl. No.:
8/476100
Inventors:
Samuel I. Miller - Brookline MA
John J. Mekalanos - Cambridge MA
John J. Mekalanos - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 121, C12N 1531, C12N 1563
US Classification:
4352523
Abstract:
A vector capable of integrating into the chromosome of Salmonella including a first DNA sequence encoding a heterologous protein, a second DNA sequence encoding a marker, and a third DNA sequence encoding a phoP regulatory region regulated gene product necessary for virulence, the third DNA sequence being mutationally inactivated.
Salmonella Vaccines
US Patent:
5695983, Dec 9, 1997
Filed:
Jul 6, 1994
Appl. No.:
8/271354
Inventors:
Samuel I. Miller - Brookline MA
John J. Mekalanos - Cambridge MA
John J. Mekalanos - Cambridge MA
Assignee:
The General Hospital Corporation - Boston MA
President and Fellows of Harvard College - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 120, C12N 136
US Classification:
4352528
Abstract:
A bacterial cell the virulence of which is attentuated by a first mutation in a PhoP regulon and a second mutation in an aromatic amino acid synthetic gene and bacterial cells the virulence of which is attenuated by a mutation in one or more PhoP-activated genes or one or more PhoP-repressed genes.