Inventors:
Samit Hirawat - Chatham NJ, US
Langdon Miller - Lebanon NJ, US
Gary Elfring - Lebanon NJ, US
Thomas Davis - South Orange NJ, US
Marla L. Weetall - Morristown NJ, US
International Classification:
A61K 38/20, A61K 38/21, A61K 39/395, A61K 31/66, A61K 31/551, A61K 31/5377, A61K 31/497, A61K 31/506, C07D 413/14, C07D 471/04, A61P 35/00
US Classification:
424 852, 424 857, 4241331, 514130, 514218, 5142328, 51425303, 51425505, 514275, 540575, 544126, 544331, 544361, 544405
Abstract:
In accordance with the present invention, compounds are provided which are useful in a method or in the manufacture of a medicament for post-transcriptionally inhibiting the expression of VEGF in a subject in need thereof comprising inhibiting VEGF mRNA translation by orally administering said medicament once, twice or thrice daily to the subject.