Inventors:
Yang Liu - Ann Arbor MI, US
Yin Wang - Ann Arbor MI, US
Yan Liu - Ann Arbor MI, US
Sami N. Malek - Ann Arbor MI, US
Pan Zheng - Ann Arbor MI, US
Assignee:
ONCOIMMUNE INC. - Ann Arbor MI
International Classification:
A61K 38/12, A61P 35/00
Abstract:
The present invention relates to treating a hematologic cancer using a Hypoxia- Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.