Inventors:
Charles A. Dvorak - Palo Alto CA
Douglas L. Wren - Palo Alto CA
Lawrence E. Fisher - Mountain View CA
Steven D. Axt - San Jose CA
Eric R. Humphreys - San Bruno CA
Humberto B. Arzeno - Cupertino CA
Colin C. Beard - Palo Alto CA
Sam Linh Nguyen - Denver CO
Yeun-Kwei Han - Louisville CO
Christopher R. Roberts - Berthoud CO
Jan P. Lund - Boulder CO
Paul R. Fatheree - San Francisco CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C07C 67743, C07C 6702
Abstract:
Intermediates of Formula (III) ##STR1##
wherein Y. sup. 1 is acyloxy, wherein acyl is of the formula R--C(O)--, wherein R is alkyl of 1-6 carbon atoms, Y. sup. 2 is aralkyloxy, and Z is benzoyloxy or acyloxy, wherein acyl is as defined above.
Intermediates of formula (III) are useful in a novel process for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol (ganciclovir). The mono-L-valine ester of ganciclovir and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.