DR. SALOMON AMAR, DDS, PH.D.
Dentist at Harvard St, Brookline, MA
License number
Massachusetts 19260
Category
Dentist
Type
Periodontics
License number
Massachusetts 045422-1
Category
Dentist
Type
Periodontics
Address
Address
284 Harvard St, Brookline, MA 02446
Phone
(617) 731-6767
Organization information
See more information about SALOMON AMAR at bizstanding.comSalomon Amar DDS,DMD,PHD
284 Harvard St, Brookline, MA 02446
Industry:
Dentists
Phone:
(617) 731-6767 (Phone)
Salomon Amar
Professional information
Salomon Amar, Brookline MA
Specialties:
Dentist
Address:
284 Harvard St, Brookline, MA 02446
Regulation Of Litaf Modulated Cytokine Production By A Novel P53 Short Peptide
US Patent:
2011005, Mar 3, 2011
Filed:
Aug 9, 2007
Appl. No.:
12/377545
Inventors:
Salomon Amar - Brookline MA, US
Xiaoren Tang - Winchester, MA
Xiaoren Tang - Winchester, MA
International Classification:
A61K 38/08, C07K 7/06, C07H 21/04, C12N 15/63, C07K 16/00, C07K 7/08, C07K 14/00, C12N 5/00, C40B 30/04, A61P 3/10, A61P 29/00, A61P 17/02
US Classification:
514 133, 530329, 536 231, 4353201, 5303879, 530328, 530327, 530326, 530325, 530324, 530350, 435375, 435455, 506 9
Abstract:
The present invention relates to a novel isolated and purified peptide of the sequence KQSQHMT [SEQ ID NO: 1], nucleic acid sequences encoding said peptide sequence and capable of expressing said sequence as an exogenous protein in a target cell; as well as methods for the reduction or inhibition of LITAF activity by transfecting the peptide KQSQHMT [SEQ ID NO: 1] or a nucleic acid capable of expressing said peptide, into a target cell. The present invention also relates to the use of the novel peptide (and corresponding nucleotide sequences) of the present invention for the regulation of cytokine expression in target cells. The present invention also relates to the use of the novel peptide (and corresponding nucleotide sequences) of the present invention for the regulation of inflammatory responses in mammals.
Transcription Factor Regulating Tnf-
US Patent:
6566501, May 20, 2003
Filed:
Apr 12, 2000
Appl. No.:
09/547461
Inventors:
Salomon Amar - Brookline MA
Assignee:
Trustees of Boston University Boston - MA
International Classification:
C07K 1400
US Classification:
530350, 530351, 536 241, 435 695, 435 711
Abstract:
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from -550 to -487 in the promoter of the human TNF- gene. Additionally, the level of the mRNA transcript encoding the isolated polypeptide is substantially increased in response to LPS stimulation in cultured THP-1 cells.
Pimap39 Modulates Lps-Induced Inflammatory Response
US Patent:
8329643, Dec 11, 2012
Filed:
Jun 24, 2009
Appl. No.:
13/000545
Inventors:
Salomon Amar - Brookline MA, US
Xiaoren Tang - Winchester MA, US
Xiaoren Tang - Winchester MA, US
Assignee:
Trustees of Boston University - Boston MA
International Classification:
A61P 29/00, A61P 31/00, C12N 15/63, C07H 21/04
US Classification:
514 21, 4353201, 514 122, 514921, 530324, 536 235
Abstract:
The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO. : 1) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administration of the peptide of the present invention. Furthermore, the present invention relates to the modulation of the expression of cytokines effected as part of an inflammatory response by administration of the peptide of the present invention.
Litaf Binding Site Peptides And Methods Of Using The Same
US Patent:
7361735, Apr 22, 2008
Filed:
Mar 10, 2004
Appl. No.:
10/796947
Inventors:
Salomon Amar - Brookline MA, US
Xiaoren Tang - Winchester MA, US
Xiaoren Tang - Winchester MA, US
Assignee:
Trustees of Boston University - Boston MA
International Classification:
C07K 1/00, A61K 38/16, C12N 15/00
US Classification:
530350, 530358
Abstract:
The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-α factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-α, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-α.
Transcription Factor Regulating Tnf-Α
US Patent:
7626007, Dec 1, 2009
Filed:
Apr 2, 2003
Appl. No.:
10/405738
Inventors:
Salomon Amar - Brookline MA, US
Assignee:
Trustees of Boston University - Boston MA
International Classification:
A01N 43/04, A61K 31/70, C07H 19/00, C07H 21/00
US Classification:
536 231, 536 221, 536 241, 514 44
Abstract:
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in the promoter of the human TNF-α gene. Additionally, the level of the mRNA transcript encoding the isolated polypeptide is substantially increased in response to LPS stimulation in cultured THP-1 cells.
Litaf Binding Site Peptides And Methods Of Using The Same
US Patent:
7981675, Jul 19, 2011
Filed:
Feb 20, 2008
Appl. No.:
12/033998
Inventors:
Salomon Amar - Brookline MA, US
Xiaoren Tang - Winchester MA, US
Xiaoren Tang - Winchester MA, US
International Classification:
C12N 15/09, C12N 15/00
US Classification:
435455, 435 691
Abstract:
The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-α factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL (SEQ ID NO: 5), or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-α, where treatment involves the modulation of this expression. The invention also provides methods for identifying compounds that inhibit or enhance the transcription of TNF-α.
Transcriptional Regulation Of Cytokines By Litaf And Stat (6)(B)
US Patent:
2009006, Mar 5, 2009
Filed:
Feb 23, 2006
Appl. No.:
11/884854
Inventors:
Salomon Amar - Brookline MA, US
Xiaoren Tang - Winchester MA, US
Xiaoren Tang - Winchester MA, US
International Classification:
A61K 38/00, C12N 15/00, C07K 14/00, C12N 5/06, A61P 31/00, A61K 31/7088, A01K 67/027, C40B 30/04
US Classification:
514 12, 4353201, 530350, 435325, 435375, 800 13, 800 15, 800 16, 800 18, 506 9, 514 44
Abstract:
The present invention relates to novel proteins (LITAF and STAT6(B)) and the nucleotide sequences encoding the same. The present invention also relates to the use of the novel peptides and nucleotide sequences of the present invention, or functional fragments thereof, for the regulation of cytokine expression. The present invention also relates to the use of the novel proteins and nucleotides sequences of the present invention for the regulation of inflammatory responses in mammals including the regulation of angiogenesis and tubulogenesis. Also in this regard, the present invention relates to the generation of null mutant animals deficient in the expression of one or both of the proteins of the present invention.