DR. SALLY J DENARDO, M.D.
Osteopathic Medicine at X St, Sacramento, CA
License number
California G12877
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
2
4501 X St SUITE 3016, Sacramento, CA 95817
44336 Clubhouse Dr, Davis, CA 95618
44336 Clubhouse Dr, Davis, CA 95618
Phone
(916) 734-3787
(916) 451-2857 (Fax)
(916) 451-2857 (Fax)
Professional information
Construction Of A Multivalent Scfv Through Alkyne-Azide 1,3-Dipolar Cycloaddition
US Patent:
2009023, Sep 17, 2009
Filed:
Mar 26, 2007
Appl. No.:
12/294227
Inventors:
Jacquelyn Gervay-Hague - Davis CA, US
Wenjun Du - St. Louis MO, US
Sally Denardo - El Macero CA, US
Arutselvan Natarajan - Sacramento CA, US
Wenjun Du - St. Louis MO, US
Sally Denardo - El Macero CA, US
Arutselvan Natarajan - Sacramento CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C07K 16/46, A61P 35/00
US Classification:
5303873
Abstract:
The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.
Sally L Denardo, Sacramento CA
Specialties:
Nuclear Medicine Specialist
Address:
1508 Alhambra Blvd, Sacramento, CA 95816
Education:
University of Chicago, Pritzker School of Medicine - Doctor of Medicine
Stanford Hospital & Clinics - Fellowship - Hematology and Oncology (Internal Medicine)
Stanford Hospital & Clinics - Fellowship - Nuclear Medicine
Stanford Hospital & Clinics - Residency - Internal Medicine
Stanford Hospital & Clinics - Fellowship - Hematology and Oncology (Internal Medicine)
Stanford Hospital & Clinics - Fellowship - Nuclear Medicine
Stanford Hospital & Clinics - Residency - Internal Medicine
Board certifications:
American Board of Nuclear Medicine Certification in Nuclear Medicine
Sally Jacobson Denardo, Sacramento CA
Specialties:
Nuclear Medicine, Internal Medicine
Work:
Radiodiagnosis & Therapy Molecular
1508 Alhambra Blvd, Sacramento, CA 95816
1508 Alhambra Blvd, Sacramento, CA 95816
Education:
University of Chicago (1965)
Dr. Sally J Denardo, Sacramento CA - MD (Doctor of Medicine)
Specialties:
Nuclear Medicine
Address:
4501 X St STE 3016, Sacramento 95817
(916) 734-3787 (Phone), (916) 734-1655 (Fax)
(916) 734-3787 (Phone), (916) 734-1655 (Fax)
Certifications:
Nuclear Medicine, 1972
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
4501 X St STE 3016, Sacramento 95817
UC Davis Medical Center
2315 Stockton Blvd, Sacramento 95817
UC Davis Medical Center
2315 Stockton Blvd, Sacramento 95817
Education:
Medical School
Center Of Chicago / Pritzker School Of Medicine
Stanford Med Ctr
Center Of Chicago / Pritzker School Of Medicine
Stanford Med Ctr
Method For Preparing Radionuclide-Labeled Chelating Agent-Ligand Complexes
US Patent:
5958374, Sep 28, 1999
Filed:
Dec 17, 1996
Appl. No.:
8/767702
Inventors:
Claude F. Meares - Davis CA
Min Li - Davis CA
Sally J. DeNardo - El Macero CA
Min Li - Davis CA
Sally J. DeNardo - El Macero CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 5100, C07F 500
US Classification:
424 165
Abstract:
Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as. sup. 90 Y or. sup. 111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.
Selective High-Affinity Polydentate Ligands And Methods Of Making Such
US Patent:
2011014, Jun 16, 2011
Filed:
Apr 21, 2009
Appl. No.:
12/988801
Inventors:
Sally J. Denardo - El Macero CA, US
Gerald L. Denardo - El Macero CA, US
Rodney L. Balhorn - Livermore CA, US
Gerald L. Denardo - El Macero CA, US
Rodney L. Balhorn - Livermore CA, US
International Classification:
A61K 31/655, C07C 245/08, C12Q 1/02, A61P 35/00
US Classification:
514150, 534798, 435 29
Abstract:
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
Anti-Muc-1 Single Chain Antibodies For Tumor Targeting
US Patent:
7183388, Feb 27, 2007
Filed:
May 9, 2003
Appl. No.:
10/435614
Inventors:
Sally Joan Denardo - El Macero CA, US
Michelle Denise Winthrop - Woodland CA, US
Gerald Louis Denardo - El Macero CA, US
Cheng-Yi Xiong - Elk Grove CA, US
Michelle Denise Winthrop - Woodland CA, US
Gerald Louis Denardo - El Macero CA, US
Cheng-Yi Xiong - Elk Grove CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C07K 16/00, C12P 21/08, A61K 39/395, C12P 21/04
US Classification:
5303873, 5303881, 53038822, 53038885, 5303913, 5303917, 4241331, 4241351, 4241411, 4241431, 4241561, 4241811, 4241831, 435 696
Abstract:
This invention provides novel antibodies that specifically bind to the cancer antigen MUC-1. The antibodies are useful targeting moieties for specifically directing imaging agents and various therapeutic moieties to a cancer.
Selective High Affinity Polydentate Ligands And Methods Of Making Such
US Patent:
7662785, Feb 16, 2010
Filed:
Feb 9, 2005
Appl. No.:
11/055181
Inventors:
Sally DeNardo - El Macero CA, US
Gerald DeNardo - El Macero CA, US
Rodney Balhorn - Livermore CA, US
Gerald DeNardo - El Macero CA, US
Rodney Balhorn - Livermore CA, US
Assignee:
The Regents of California - Oakland CA
Lawrence Livermore National Security, LLC - Livermore CA
Lawrence Livermore National Security, LLC - Livermore CA
International Classification:
A61K 38/08
US Classification:
514 17, 514182, 514393
Abstract:
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
Anti-Muc-1 Single Chain Antibodies For Tumor Targeting
US Patent:
2003007, Apr 24, 2003
Filed:
Mar 28, 2002
Appl. No.:
10/112788
Inventors:
Sally Denardo - El Macero CA, US
Michelle Winthrop - Woodland CA, US
Gerald Denardo - El Macero CA, US
Michelle Winthrop - Woodland CA, US
Gerald Denardo - El Macero CA, US
Assignee:
University of California, Davis Technology Transfer Center
International Classification:
G01N033/574, C07K016/30
US Classification:
435/007230, 530/388260, 530/388800
Abstract:
This invention provides novel antibodies that specifically bind to the cancer antigen MUC-1. The antibodies are useful targeting moieties for specifically directing imaging agents and various thereapeutic moieties to a cancer.
On-Demand Cleavable Linkers For Radioconjugates For Cancer Imaging And Therapy
US Patent:
2005025, Nov 17, 2005
Filed:
Nov 23, 2004
Appl. No.:
10/997759
Inventors:
Kit Lam - Davis CA, US
Pappanaicken Kumaresan - Sacramento CA, US
Sally DeNardo - Sacramento CA, US
Gerald DeNardo - Sacramento CA, US
Pappanaicken Kumaresan - Sacramento CA, US
Sally DeNardo - Sacramento CA, US
Gerald DeNardo - Sacramento CA, US
Assignee:
The Regents of the University of California Office of Technology Transfer, University of California - Oakland CA
International Classification:
A61K051/00
US Classification:
424001490
Abstract:
The present invention provides compositions comprising a biological agent, a targeting moiety, and a peptide linker attaching the biological agent to the targeting moiety, wherein the peptide linker is selectively cleaved by a protease. Efficient methods are provided for administering the compositions of the present invention for treating cancer or imaging a tumor, organ, or tissue in a subject. Kits are also provided for administering the compositions of the present invention for radiotherapy or radioimaging.