Inventors:
Thomas Meitinger - Munich, DE
Tim Matthias Strom - Munich, DE
Saskia Biskup - Stuttgart, DE
Marius Ueffing - Munich, DE
Elisabeth Kremmer - Freising, DE
Christian Johannes Gloeckner - Rottenburg-Hailfingen, DE
Thomas Gasser - Tuebingen, DE
Petra Herzig - Basel, CH
Friedrich Asmus - Teubingen, DE
Nadja Patenge - Rostock, DE
Alexander Zimprich - Vienna, AT
Matthew J. Farrer - Jacksonville FL, US
Jennifer M. Kachergus - Atlantic Beach FL, US
Sara J. Lincoln - Jacksonville FL, US
Mary M. Hulihan - Atlanta GA, US
Zibigniew Wszolek - Jacksonville FL, US
Ryan Uitti - Jacksonville FL, US
Assignee:
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) - Neuheberg
Eberhard-Karls-Universitaet Tuebingen - Tuebingen
Mayo Foundation For Medical Education and Research - Jacksonville FL
International Classification:
C12Q 1/68
Abstract:
The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.