Inventors:
Ryan A. Wilcox - Rochester MN, US
Thomas E. Witzig - Rochester MN, US
Assignee:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN
International Classification:
A61K 39/395, A61P 35/00, A61P 29/00, A61P 37/04
Abstract:
This document provides methods and materials involved in depleting immunosuppressive monocytes (e.g., CD14/DR or CD14/DRmonocytes) within a mammal. For example, methods and materials involved in using a CD2 binding molecule (e.g., alefacept) to deplete immunosuppressive monocytes within a mammal (e.g., a human) are provided.