RUTH KJELGAARD FOREMAN
Medical Practice in Somerville, MA
License number
Pennsylvania MD452277
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Somerville, MA 02145
Pennsylvania
Pennsylvania
Professional information
Reprogramming Of Somatic Cells
US Patent:
2011007, Mar 31, 2011
Filed:
Apr 7, 2008
Appl. No.:
12/595041
Inventors:
Rudolf Jaenisch - Brookline MA, US
Jaqub Hanna - Boston MA, US
Marius Wernig - Woodside CA, US
Christopher J. Lengner - Wellesley MA, US
Alexander Meissner - Cambridge MA, US
Oliver Tobias Brambrink - Cambridge MA, US
G. Grant Welstead - Cambridge MA, US
Ruth Foreman - Somerville MA, US
Jaqub Hanna - Boston MA, US
Marius Wernig - Woodside CA, US
Christopher J. Lengner - Wellesley MA, US
Alexander Meissner - Cambridge MA, US
Oliver Tobias Brambrink - Cambridge MA, US
G. Grant Welstead - Cambridge MA, US
Ruth Foreman - Somerville MA, US
International Classification:
C12Q 1/68, C12N 5/071, C12N 15/85, C12N 15/86, C12N 15/87
US Classification:
435 6, 435325, 435455, 435456, 435462, 435377
Abstract:
The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
Wnt Pathway Stimulation In Reprogramming Somatic Cells
US Patent:
2010031, Dec 9, 2010
Filed:
Aug 29, 2008
Appl. No.:
12/675681
Inventors:
Brett Chevalier - Malden MA, US
Alexander Marson - Cambridge MA, US
Richard A. Young - Weston MA, US
Ruth Foreman - Somerville MA, US
Rudolf Jaenisch - Brookline MA, US
Alexander Marson - Cambridge MA, US
Richard A. Young - Weston MA, US
Ruth Foreman - Somerville MA, US
Rudolf Jaenisch - Brookline MA, US
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
A61K 35/12, C12N 5/071, C12Q 1/04, G01N 33/567, C12Q 1/02, A61P 7/06, A61P 37/02, A61P 25/28, A61P 25/16, A61P 25/00, A61P 5/00, A61P 17/02
US Classification:
424 937, 435375, 435366, 435377, 435 34, 435 721, 435 29
Abstract:
The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.