Inventors:
W. GILLIES MCKENNA - PHILADELPHIA PA, US
RUTH J. MUSCHEL - PHILADELPHIA PA, US
ERIC J. BERNHARD - PHILADELPHIA PA, US
SAID M. SEBTI - TAMPA FL, US
ANDREW D. HAMILTON - PITTSBURGH PA, US
International Classification:
A61M036/14, A61K051/00, A01N037/18, A61K038/00, C12Q001/00, C12Q001/68, G01N033/53, A61K038/16, A61K031/70, A01N043/04, A61K039/395, A61K031/545, G01N033/52
US Classification:
435/004000, 514/002000, 514/044000, 435/006000, 435/007100, 424/130100, 424/001110
Abstract:
The invention relates to a method of conferring radiation sensitivity on a tumor cell comprising administering to the cell an inhibitor of a protein product which participates in the ras signalling pathway, whereby inhibition of the protein product confers radiation sensitivity on the cell.