Inventors:
Rachel Slade - Salt Lake City UT, US
Yevgeniya Klimova - Sandy UT, US
Robert J. Halter - Salt Lake City UT, US
Ashantai J. Yungai - Salt Lake City UT, US
Warren S. Weiner - Salt Lake City UT, US
Ruth J. Walton - Bountiful UT, US
Jon Adam Willardsen - Riverton UT, US
Mark B. Anderson - Orinda UT, US
Kenton Zavitz - Salt Lake City UT, US
Assignee:
Myrexis, Inc. - Salt Lake City UT
International Classification:
A61K 31/5377, A61K 31/4985, A61K 31/437, A61K 31/4439, C07D 413/14, A61K 31/422, A61K 31/403, C07D 403/10, C07D 209/18, C07D 413/10, A61K 31/501, C07D 471/06, C07D 401/04, C07D 417/04, C07D 413/04, C07D 491/10, C07D 209/90, A61K 31/404, C07D 209/12, C07D 413/08, C07D 401/14, C07D 405/14, A61P 25/28, A61K 31/5025
US Classification:
5142352, 514248, 514250, 51425201, 51425505, 514292, 514339, 514365, 514378, 514409, 514411, 514415, 514419, 544143, 544234, 544238, 544405, 546 84, 5462767, 5462774, 548214, 548247, 548254, 548411, 548427, 548509, 548510
Abstract:
The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH, -L-C(═O)NH(Calkyl), -L-C(═O)N(Calkyl), -L-S(═O)(Calkyl), -L-S(═O)NH, -L-S(═O)N(Calkyl), -L-S(═O)NH(Calkyl), -L-C(═O)NHOH, -L-C(═O)CHNH, -L-C(═O)CHOH, -L-C(═O)CHSH, -L-C(═O)NHCN, -L-NHC(═O)OR, -L-C(═O)NHR, -L-NH(C═O)NHR, -L-C(═O)N(R), -L-NH(C═O)N(R), -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.