Russell Kent Stewart
Architects in Salt Lake City, UT

2010030, Dec 2, 2010

Nov 13, 2008

12/864045

Russell John Stewart - Salt Lake City UT, US
Hui Shao - Salt Lake City UT, US

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

A61B 17/56, A61C 5/04, C08F 22/10, C08F 226/06, C07K 2/00, B05D 5/10

606 86 R, 433226, 525 50, 5253282, 5253267, 530402, 523105, 4272071, 427 226

Described herein is the synthesis of adhesive complex coacervates. The adhesive complex coacervates are composed of a mixture of one or more polycations, one or more poly anions, and one of more multivalent cations. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

2013018, Jul 25, 2013

Sep 14, 2012

13/617882

Russell J. Stewart - Salt Lake City UT, US
Hui Shao - Salt Lake City UT, US

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

A61L 24/00, A61F 2/28, C08L 33/26

424400, 525209, 5147724, 623 2362

Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. They have numerous biological applications as bioadhesives and drug delivery devices and are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

5830659, Nov 3, 1998

Sep 13, 1996

8/713815

Russell J. Stewart - Salt Lake City UT

University of Utah Research Foundation - Salt Lake City UT

C12Q 168, C12Q 134, G01N 33566, C12M 140

435 6

A method and system for separating a selected molecule from a heterogeneous mixture of molecules in aqueous solution are described. The method comprises (a) providing a separation device comprising a loading reservoir and a receiving reservoir coupled by a channel bearing immobilized microtubules aligned parallel to the longitudinal axis thereof the channel; (b) placing an aqueous solution containing the heterogeneous mixture of molecules in the loading reservoir; (c) adding a motor-ligand composition and ATP to the aqueous solution, wherein the motor-ligand composition comprises a motor protein for attaching to microtubules and moving therealong in the presence of ATP and the ligand is capable of binding the selected molecule, such that the ligand binds the selected molecule to form a complex and the complex moves along the immobilized microtubules to the receiving reservoir; and (d) removing the selected molecule from the receiving chamber.

8283384, Oct 9, 2012

Jul 23, 2009

12/508280

Russell J Stewart - Salt Lake City UT, US
Hui Shao - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

A61K 47/30, A61P 19/08

5147721

Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i. e. , they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.

2010026, Oct 21, 2010

Aug 11, 2004

10/567992

Russell John Stewart - Salt Lake City UT, US
Patrick Franklin Kiser - Salt Lake City UT, US
Richard Scott Staynor - Minneapolis MN, US

University of Utah Research Foundation - Salt Lake City UT

C12Q 1/70, C12Q 1/68, G01N 33/53

435 5, 435 6, 435 75, 436 86, 436 90, 977902, 977924

Crosslinked proteins, proteins and polymers, and polymers and methods of making the same are disclosed. In one illustrative embodiment, a method is provided comprising the steps of attaching a chelator to one or more polymers; creating a coordination complex between the first protein, the second protein, and a metal ion; and crosslinking the first and second proteins by exposing the coordination complex to an oxidant.

2010024, Sep 30, 2010

Sep 22, 2008

12/679050

Russell J. Stewart - Salt Lake City UT, US
Betsy J. Endrizzi - Sandy UT, US
Gang Huang - Salt Lake City UT, US
Vladimir Hlady - Salt Lake City UT, US
Samuel Aaron Poff - Salt Lake City UT, US

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

G01N 33/53, C25D 11/00

436501, 205 50, 205 81, 205317

Described herein are methods for electrodepositing a variety of different polymers on metal substrates. The polymers are strongly adhered to the substrates. The substrates produced herein can be used in a number of different applications such as, for example, medical devices and biosensors. For example, the biosensors can be composed of one or more electrodes, where the electrodes have the same or different polymers electrochemically deposited on them. Finally, the methods described herein permit the evaluation of the electrodeposition process as well as monitor the ability of biomolecules to bind to the electrodeposited polymers.

2013012, May 23, 2013

Feb 25, 2011

13/580794

Russell J. Stewart - Salt Lake City UT, US

C07K 14/00

424400, 530353, 424682, 424641, 424639, 424653, 424647, 514 167, 514773, 514 208, 514 135, 1061241, 428221

Described herein is the synthesis of adhesive complex coacervates from electrostatically associated block copolymers, wherein the block copolymers comprise alternating polycationic and polyanionic blocks. Methods for making and the using the adhesive complex coacervates are also described herein.

2007016, Jul 19, 2007

Mar 28, 2005

10/594196

Patrick Kiser - Salt Lake City UT, US
David Katz - Chapel Hill NC, US
Russell Stewart - Salt Lake City UT, US

A61K 9/14, A61K 31/765

424486000, 424078380

The polymer systems of the present invention degrade in the presence of an ejaculate. They may further provide degradable sequences that degrade upon contact with an ejaculate and/or microbicides. The polymer systems of the present invention are of use in the oral, rectal or vaginal cavities of an individual for such purposes as the treatment or prevention of sexually transmitted disease, the prevention or promotion of fertility or for hormone replacement therapy.

2012017, Jul 12, 2012

Nov 12, 2011

13/295061

Russell J. STEWART - Salt Lake City UT, US

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

C09J 7/02, C09J 199/00, C09J 103/00, C09J 179/02, C09J 189/00

428355 R, 524612, 1061241, 1061621, 106218, 522173

Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications.

7179487, Feb 20, 2007

Jun 18, 1999

09/336259

Jindrich Kopecek - Salt Lake City UT, US
Russell Stewart - Salt Lake City UT, US
Karin Caldwell - Salt Lake City UT, US
Chung Wang - Salt Lake City UT, US
Chih-Hu Ho - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

A61K 9/00, A61K 38/03, A61K 38/16

424484, 424486, 530300, 514 2, 514 42, 514 44

A stimuli-responsive, hybrid hydrogel wherein the bulk of the polymer is made up of relatively inexpensive water soluble polymer strands crosslinked by protein domains. The responsiveness of the gel is controlled or modulated by the protein component. The physical and biological properties of the hydrogel are determined by specifically designed or engineered protein domains. The crosslinking of the protein domains to the water soluble polymers is by means of non-covalent bonding such as chelation or coordination bonding, biotin-avidin bonding, protein—protein interaction and protein-ligand interaction, or by means of covalent bonding. Methods of making and using the polymer-protein hydrogels are disclosed in this application.