Inventors:
Rupal S. BHATT - Roslindale MA, US
Ravindra Kumar - Acton MA, US
James W. Mier - Brookline MA, US
Robert Pearsall - Woburn MA, US
Matthew Sherman - Newton MA, US
Nicolas Solban - Brighton MA, US
International Classification:
A61K 38/45, A61K 31/404, A61K 31/44, A61K 31/436, A61K 31/4439, A61K 31/4709, A61K 31/517, A61K 39/395, A61K 31/506
US Classification:
4241341, 424 945, 4241391
Abstract:
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit tumor growth of renal cell carcinoma (RCC) in vivo. In additional aspects the disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of ALK1 dramatically increases the ability of a standard of care receptor tyrosine kinase inhibitor to inhibit RCC tumor growth in vivo.