Inventors:
Ruey J. Yu - Chalfont PA, US
Eugene J. Van Scott - Abington PA, US
International Classification:
A61K 31/662, C07F 9/38, A61P 31/12, A61P 31/10, A61P 31/04, A61P 17/00, A61P 1/08, A61P 29/00, A61Q 15/00, A61P 25/22, A61P 25/24, A61Q 17/04, A61P 17/12, A61Q 19/00, A61P 17/02, C07F 9/572, A61K 31/675, C07K 5/037, A61K 38/06, A61K 8/55, A61K 39/395, A61K 38/38, A61K 38/20, A61K 38/48, A61K 33/06, A61K 31/7048
US Classification:
424 59, 562 17, 514114, 424 65, 424 701, 548413, 514 91, 530331, 514 219, 4241331, 4241421, 514 152, 424 852, 424 9464, 424685, 514 29
Abstract:
The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)-glycine. Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.