Inventors:
Rudolph L. Leibel - New York NY, US
Wendy K. Chung - Hackensack NJ, US
Charles LeDuc - Hackensack NJ, US
Stuart G. Fischer - New Rochelle NY, US
Chouinard Roland - Fort Lee NJ, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
G01N 33/50
US Classification:
800 3, 506 9, 530350, 5303879, 536 235, 435 79, 435 612, 435375, 424 937, 514 44 R, 514 69, 604522
Abstract:
The invention provides methods for reducing diabetes susceptibility in a subject and methods for increasing the expression of LL or CLORF32 in a subject. The invention further provides a method for identifying an agent which modulates expression of an Ll RNA or Clorf32 RNA comprising contacting a cell with an agent; determining expression of the Ll RNA or Clorf32 RNA in the presence and the absence of the agent; and comparing expression of the Ll RNA or Clorf32 RNA in the presence and the absence of the agent, wherein a change in the expression of the Ll RNA or Clorf32 RNA in the presence of the agent is indicative of an agent which modulates the level of expression of the RNA.