Inventors:
Ronald A. DePinho - Houaton TX, US
Kenneth C. Anderson - Wellesley MA, US
Ruben D. Carrasco - Brookline MA, US
Giovanni Tonon - Cernusco Sul Naviglio, IT
Cameron W. Brennan - Haworth NJ, US
Lynda Chin - Houston TX, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
Board of Trustees of the University of Arkansas - Little Rock AR
International Classification:
C12Q 1/68, G01N 33/53, G01N 33/574
Abstract:
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.