ROYDEN M COE
Pharmacy in Chesterfield, NJ
License number
New Jersey 28RI01392600
Issued Date
Jan 1, 1974
Expiration Date
Apr 30, 2019
Category
Pharmacy
Type
Pharmacist
Address
Address
Chesterfield, NJ
Professional information
Liposome Extrusion Process
US Patent:
6623671, Sep 23, 2003
Filed:
Nov 20, 2001
Appl. No.:
09/988665
Inventors:
Royden M. Coe - Bordentown NJ 08505
Robert L. Thies - Vancouver, British Columbia V6R 3M8, CA
Joel B. Portnoff - Richboro PA 18954
Robert L. Thies - Vancouver, British Columbia V6R 3M8, CA
Joel B. Portnoff - Richboro PA 18954
International Classification:
B01J 1320
US Classification:
264 43, 424450, 4284022
Abstract:
A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film by entering the film via the smaller pores and extruded via the larger pores, under pressure, is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a predetermined maximum size. Also disclosed is an apparatus for carrying out the invention.
Formulation Preparation Device
US Patent:
5583052, Dec 10, 1996
Filed:
May 23, 1995
Appl. No.:
8/447660
Inventors:
Joel B. Portnoff - Langhorne PA
Royden M. Coe - Bordentown NJ
John Grimm - Schnecksville PA
Kenneth Raines - Bethlehem PA
Joel Bartholomew - Danielsville PA
Royden M. Coe - Bordentown NJ
John Grimm - Schnecksville PA
Kenneth Raines - Bethlehem PA
Joel Bartholomew - Danielsville PA
Assignee:
The Liposome Company, Inc. - Princeton NJ
B. Braun Medical, Inc. - Bethlehem PA
B. Braun Medical, Inc. - Bethlehem PA
International Classification:
G01N 110
US Classification:
436180
Abstract:
A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has an enclosed, sterilizable, gripable housing and can be used to mix combine fluids in reproducible and predetermined proportions. Combination is accomplished aseptically, avoiding contact between the device's operator and the fluids and the substances combined. Biologically active compounds can be combined with one or more fluids, including such aqueous liposome suspensions, using the device. A formulation preparation kit containing, in addition to the device, the fluids and compounds to be formulated is thus also provided herein; methods of using the device to prepare such formulations are further provided herein.
Method Of Producing Liposomes
US Patent:
5540936, Jul 30, 1996
Filed:
Jun 2, 1994
Appl. No.:
8/253145
Inventors:
Royden M. Coe - Bordentown NJ
Lawrence Boni - Monmouth Junction NJ
Joel Portnoff - Richboro PA
Sharma R. Minchey - Monmouth Junction NJ
Lawrence Boni - Monmouth Junction NJ
Joel Portnoff - Richboro PA
Sharma R. Minchey - Monmouth Junction NJ
Assignee:
The Liposome Company, Inc. - Princeton NJ
International Classification:
A61K 9127
US Classification:
424450
Abstract:
This invention provides a process for the production of liposomes by combining an organic phase and an aqueous at a volume ratio of less than 3:1; the process can be conducted under conditions which obtain a single-modal population distribution of liposomes encompassing a pre-selected mean particle size. A novel intermediate product obtained during the process, which can itself be used for the topical delivery of a bioactive agent, is also provided.