DR. ROY CHARLES ORLANDO, MD
Osteopathic Medicine at Manning Dr, Chapel Hill, NC
License number
North Carolina 09456R
Category
Osteopathic Medicine
Type
Gastroenterology
License number
North Carolina 17277
Category
Osteopathic Medicine
Type
Gastroenterology
Address
Address
101 Manning Dr, Chapel Hill, NC 27599
Phone
(919) 843-4583
Personal information
See more information about ROY CHARLES ORLANDO at radaris.comName
Address
Phone
2006 Marions Ford Rd, Chapel Hill, NC 27516
340 Triple Creek Dr, Efland, NC 27243
3205 Spoon Ln, Mebane, NC 27302
Professional information
Dr. Roy C Orlando, Chapel Hill NC - MD (Doctor of Medicine)
Specialties:
Gastroenterology
Address:
Gastroenterology/Hepatolgy Clinic
101 Manning Dr, Chapel Hill 27514
(919) 966-6000 (Phone)
101 Manning Dr, Chapel Hill 27514
(919) 966-6000 (Phone)
Certifications:
Gastroenterology, 1973, Internal Medicine, 1972
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Georgetown University School Of Medicine
Graduated: 1968
Dc Gen Hospital
University Of Nc Hosps
Georgetown University School Of Medicine
Graduated: 1968
Dc Gen Hospital
University Of Nc Hosps
Roy Charles Orlando, Chapel Hill NC
Specialties:
Gastroenterologist
Address:
103 Mason Farm Rd, Chapel Hill, NC 27599
101 Manning Dr, Chapel Hill, NC 27514
101 Manning Dr, Chapel Hill, NC 27514
Education:
Georgetown University, School of Medicine - Doctor of Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Gastroenterology (Internal Medicine)
Protection Of Moist Stratified Squamous Epithelia Against Damage From Noxious Luminal Agents
US Patent:
5374537, Dec 20, 1994
Filed:
Nov 24, 1992
Appl. No.:
7/983089
Inventors:
Roy C. Orlando - Chapel Hill NC
Nelia A. Tobey - Raleigh NC
Nelia A. Tobey - Raleigh NC
Assignee:
University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
C12Q 102, A01N 4326, A01N 5726, A61K 3752
US Classification:
435 29
Abstract:
The present invention is related to the protection of moist stratified squamous epithelia against damage from exposure to noxious luminal agents. Protection of moist stratified squamous epithelia against these noxious luminal agents is afforded by chemical compounds having one of the following reactive groups in their molecule: X--SO. sub. 3. sup. -, where X represents oxygen or carbon, and XO. sub. 4. sup. = or X. sub. 2 O. sub. 7. sup. =, where X represents an element from group VIb or sulfur of group VIa of the periodic table. Compounds that provide protection against injury to moist stratified squamous epithelia that illustrate the protective characteristic of these reactive species are the sulfonates, the sulfate esters and the tetrahedral-shaped divalent oxy-anions of the transition metals in group VIb or of sulfur. The reason for protection by these compounds is that they stabilize the intercellular junctions of moist stratified squamous epithelia so as to prevent the increase in permeability across the junctions that normally accompanies exposure to noxious luminal agents like HCl or N-acetylcysteine.
Protection Of Moist Stratified Squamous Epithelia Against Damage From Noxious Luminal Agents
US Patent:
5189056, Feb 23, 1993
Filed:
Dec 19, 1989
Appl. No.:
7/452393
Inventors:
Roy C. Orlando - Chapel Hill NC
Nelia A. Tobey - Raleigh NC
Nelia A. Tobey - Raleigh NC
Assignee:
University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
A61K 3110, A61K 31385
US Classification:
514439
Abstract:
The present invention is related to the protection of moist stratified squamous epithelia against damage from exposure to noxious luminal agents. Protection of moist stratified squamous epithelia against these noxious luminal agents is afforded by chemical compounds having one of the following reactive groups in their molecule: X--SO. sub. 3. sup. -, where X represents oxygen or carbon, and XO. sub. 4. sup. = or X. sub. 2 O. sub. 7. sup. =, where X represents an element from group VIb or sulfur of group VIa of the periodic table. Compounds that provide protection against injury to moist stratified squamous epithelia that illustrate the protective characteristic of these reactive species are the sulfonates, the sulfate esters and the tetrahedral-shaped divalent oxy-anions of the transition metals in group VIb or of sulfur. The reason for protection by these compounds is that they stabilize the intercellular junctions of moist stratified squamous epithelia so as to prevent the increase in permeability across the junctions that normally accompanies exposure to noxious luminal agents like HCl or N-acetylcysteine.
Method For Treating Acute Alkali Exposure With Carbon Dioxide
US Patent:
5262180, Nov 16, 1993
Filed:
Nov 25, 1991
Appl. No.:
7/797781
Inventors:
Roy C. Orlando - Chapel Hill NC
R. Lee Meyers - Chapel Hill NC
R. Lee Meyers - Chapel Hill NC
Assignee:
University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
A61K 3300
US Classification:
424700
Abstract:
The present invention provides a method for combatting damage to a body tissue contacted to an alkali. The method comprising administering CO. sub. 2 to the subject in an amount sufficient to produce an acidotic state in the tissue, the acidotic state serving to prevent alkali damage to the tissue. In a preferred embodiment of the invention, a subject is caused to inhale a mixture of 95%O. sub. 2 and 5%CO. sub. 2 for brief periods of time, followed by periods of breathing room air. The invention is particularly useful for treating alkaline injury of the esophagus caused by ingestion of alkaline material.