ROSS HOWARD ALBERT
Medical Practice in Philadelphia, PA
License number
Pennsylvania MT185662
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
Philadelphia, PA 19129
Personal information
See more information about ROSS HOWARD ALBERT at radaris.comName
Address
Phone
8526 Germantown Ave, Philadelphia, PA 19118
405 Runnymede Ave, Jenkintown, PA 19046
3445 Tilden St, Philadelphia, PA 19129
2979 School House Ln, Philadelphia, PA 19144
940 Providence Rd, Media, PA 19063
Professional information
See more information about ROSS HOWARD ALBERT at trustoria.com
Immunomodulation And Effect On Cell Processes Relating To Serotonin Family Receptors
Immunomodulation And Effect On Cell Processes Relating To Serotonin Family Receptors
US Patent:
2006003, Feb 23, 2006
Filed:
Aug 4, 2005
Appl. No.:
11/197673
Inventors:
Bradford Jameson - Philadelphia PA, US
Anna Tretiakova - Philadelphia PA, US
Ross Albert - Philadelphia PA, US
Harold Davidson - Philadelphia PA, US
Anna Tretiakova - Philadelphia PA, US
Ross Albert - Philadelphia PA, US
Harold Davidson - Philadelphia PA, US
International Classification:
A61K 39/395
US Classification:
424133100, 424143100
Abstract:
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.
Immunomodulation And Effect On Cell Processes Relating To Serotonin Family Receptors
Immunomodulation And Effect On Cell Processes Relating To Serotonin Family Receptors
US Patent:
6979447, Dec 27, 2005
Filed:
Mar 29, 2002
Appl. No.:
10/112261
Inventors:
Bradford A. Jameson - Philadelphia PA, US
Anna A. Tretiakova - Philadelphia PA, US
Ross Albert - Philadelphia PA, US
Harold Carter Davidson - Philadelphia PA, US
Anna A. Tretiakova - Philadelphia PA, US
Ross Albert - Philadelphia PA, US
Harold Carter Davidson - Philadelphia PA, US
Assignee:
Philadelphia Health and Education Corporation - Philadelphia PA
International Classification:
A61K039/00, G01N033/574
US Classification:
4241841, 435 723, 435 724
Abstract:
The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.