Inventors:
Rigel Pharmaceuticals, Inc. - , US
Matthew Duncton - San Bruno CA, US
Jing Zhang - Mercer Island WA, US
Salvador Alvarez - Fremont CA, US
Kin Tso - San Francisco CA, US
Sacha Holland - San Francisco CA, US
Rose Yen - San Francisco CA, US
Rao Kolluri - Foster City CA, US
Thilo Heckrodt - San Francisco CA, US
Yan Chen - Foster City CA, US
Esteban Masuda - Menlo Park CA, US
Hui Li - Santa Clara CA, US
Donald G. Payan - Hillsborough CA, US
International Classification:
C07D 471/04, C07D 519/00
US Classification:
51421021, 544324, 514275, 435184, 544105, 5142305, 544101, 5142302, 544230, 544122, 5142332, 540548, 51421112, 544 71
Abstract:
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.