DR. ROSALIA AYUSO, MD, PHD
Osteopathic Medicine at Queens Blvd, Flushing, NY

2012021, Aug 30, 2012

Aug 2, 2010

13/387894

Rosalia Ayuso - Middle Village NY, US
Hugh A. Sampson - Greenwich CT, US
Galina Grishina - Tarry Town NY, US

MOUNT SINAI SCHOOL OF MEDICINE - New York NY

A61K 39/395, A61P 37/08, G01N 33/53

4241331, 4241721, 4241521, 436501, 435 792, 4241391

The disclosure provides materials and methods for diagnosing, treating and preventing shellfish allergic reactions, including allergic reactions to shrimp. The technology involves one or more shellfish-specific proteins selected from the group of myosin light chain, sarcoplasmic calcium-binding protein, hemocyanin, fatty acid binding protein, and troponin C, for example from shrimp, as well as encoding polynucleotides, vectors host cells, and specific binding partners for such proteins, e.g., antibodies. In compositions comprising a plurality of shellfish allergens, any of the aforementioned proteins may be included, as may arginine kinase and tropomyosin. The methods according to the disclosure include methods of making the specific binding partners such as antibodies as well as methods of using the materials of the disclosure to diagnose, treat or prevent an allergic reaction to shellfish, e.g., shrimp.