RONALD R KRUEGER, MD
Medical Practice at Euclid Ave, Cleveland, OH

2004019, Oct 7, 2004

Jan 2, 2004

10/750789

Raymond Myers - Collinsville IL, US
Ronald Krueger - Cleveland OH, US

A61B018/20, A61F002/16

606/004000, 623/006110, 623/006220, 623/006370

Methods for the creation of microspheres treat the clear, intact crystalline lens of the eye with energy pulses, such as from lasers, for the purpose of correcting presbyopia, other refractive errors, and for the retardation and prevention of cataracts. Microsphere formation in non-contiguous patterns or in contiguous volumes works to change the flexure, mass, or shape of the crystalline lens in order to maintain or reestablish the focus of light passing through the ocular lens onto the macular area, and to maintain or reestablish fluid transport within the ocular lens.

2010011, May 6, 2010

Jan 12, 2010

12/685850

Raymond I. Myers - Collinsville IL, US
Ronald Krueger - Cleveland OH, US

A61F 9/008, A61B 18/20

606 5

Methods for the creation of microspheres treat the clear, intact crystalline lens of the eye with energy pulses, such as from lasers, for the purpose of correcting presbyopia, other refractive errors, and for the retardation and prevention of cataracts. Microsphere formation in non-contiguous patterns or in contiguous volumes works to change the flexure, mass, or shape of the crystalline lens in order to maintain or reestablish the focus of light passing through the ocular lens onto the macular area, and to maintain or reestablish fluid transport within the ocular lens.

2009004, Feb 19, 2009

Aug 14, 2008

12/191663

Ronald R. Krueger - Cleveland OH, US
Holger Lubatschowski - Gehrden, DE

A61F 9/008, A61B 18/20

606 5

Systems and methods are provided for disrupting tissue within preretinal or retinal structures of an eye. At least one femtosecond laser pulse is directed through the cornea of the eye to a target location. The at least one femtosecond laser pulse has sufficient intensity to induce nonlinear absorption in tissue within the target location. The at least one laser pulse is corrected at an adaptive optical element as to substantially reduce dispersion and aberration of the at least one laser pulse due to changes in the wavefront profile associated with the laser pulse due to travel through eye tissue between the surface of the eye and the target location. At least the target location is imaged to produce an in vivo image of the target location. The adaptive optical element is adjusted according to distortion detected in a reflected wavefront.

8580789, Nov 12, 2013

Apr 2, 2008

12/593720

Ronald R. Krueger - Cleveland OH, US
William J. Dupps - Bay Village OH, US
Stephen Trokel - New York NY, US
Ivey Thornton - Cleveland OH, US

The Cleveland Clinic Foundation - Cleveland OH

A61K 31/525, A61K 31/11

514251, 514705, 514912, 514913

Provided herein are methods of protecting all or a portion of the optic nerve fiber layer within the optic nerve/lamina cribrosa (ONLC) complex in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and protecting all or a portion of the optic nerve fiber layer within the ONLC of the individual. In a particular embodiment, the invention is directed to methods of treating glaucoma in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucoma in the individual. In yet another embodiment, the invention is directed to methods of treating glaucomatous optic neuropathy in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's peripapillary sclera, thereby stiffening the individual's peripapillary sclera and treating the glaucomatous optic neuropathy in the individual. The method can further comprise administering to the individual a therapeutically effective amount of an agent that results in crosslinking of collagen in the indiviudal's lamina cribrosa (LC).