Inventors:
Ronald J. Koenig - Ann Arbor MI
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 3810
US Classification:
4241851, 4241921, 4242771, 424568, 435 721, 435 28, 436506, 530324, 530326, 530854
Abstract:
Specific epitopic regions of thyroid peroxidase (TPO), a thyroid specific membrane autoantigen, have been identified within amino acid residues 456 to 933, 457 to 633, 513 to 633, and 633 to 933 of the protein (SEQ ID NO:2), with at least one distinct binding region within TPO located from amino acid residues 592 to 613 (SEQ ID NO:7). The identification and production of these localized epitopes/epitopic regions provide specific therapeutic reagents for administration to autoimmune thyroid disease patients.