Inventors:
Ronald Malone - Chapel Hill NC, US
Cindy Xudong Yang - Tappan NY, US
Hanyoung Han - Sunnyside NY, US
Jee Loon Look - Boyds MD, US
Zhaowei Jin - Chesterfield MO, US
Ying Chen - Apex NC, US
International Classification:
A61K 39/00, A61K 39/385, C07K 1/00
US Classification:
4241841, 4241931, 42419711, 530350
Abstract:
The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e. g. , aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.