Inventors:
Zhuang Wang - Durham NC, US
Michael Edward Werner - Morrisville NC, US
James Donald Byrne - Carrboro NC, US
Ronald Chingyun Chen - Chapel Hill NC, US
Shrirang Shrikant Karve - Chapel Hill NC, US
Joseph DeSimone - Chapel Hill NC, US
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL - Chapel Hill NC
International Classification:
A61M 36/12, B82Y 5/00
Abstract:
Delivery systems adapted for implementation during a brachytherapy procedure are provided. The delivery system includes a plurality of brachytherapy seeds and a plurality of spacers. Each spacer is formed of a matrix material carrying a plurality of microparticles and/or nanoparticles. The microparticles and/or nanoparticles carry an agent and are biodegradable and/or biocompatible. The brachytherapy seeds and the spacers are configured to be delivered to a target site. Associated methods are also provided.