Inventors:
Albert H. Soloway - Worthington OH
Rolf F. Barth - Columbus OH
Abul K. Anisuzzaman - Westerville OH
Werner Tjarks - Bremen, DE
Iwona M. Wyzlic - Columbus OH
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
A61K 3170, A61K 3322, C07H 1906, C07H 2300
Abstract:
The invention relates to novel boron-containing nucleosides and amino acids which can utilize the enzymatic systems in tumor cells for incorporating such boron-containing structures into nucleic acids and proteins. Subsequent use of boron neutron capture therapy provides a method for treating tumor cells.