Inventors:
Kenneth Widder - Rancho Santa Fe CA, US
Lauren Otsuki - San Diego CA, US
Howard Dittrich - San Diego CA, US
Scott Thomson - Poway CA, US
Roland Blantz - Del Mar CA, US
International Classification:
A61K 31/549, A61K 31/522
Abstract:
Disclosed is a pharmaceutical composition comprising a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, and a non-adenosine modifying diuretic. Also disclosed are methods of inducing a diuretic effect in an animal comprising the step of administering a therapeutically effective amount of KW-3902, or a salt, ester, amide, metabolite, or prodrug thereof, in combination with second pharmaceutical composition capable of inducing a diuretic effect.