Inventors:
Roger N. Rosenberg - Dallas TX, US
Stephen A. Johnston - Tempe AZ, US
Assignee:
The Board of Regents of the University of Texas System - Austin TX
International Classification:
C07H 21/04, A01N 43/04, A61K 39/12, A61K 39/00
US Classification:
536 231, 514 44, 4241921, 4241861
Abstract:
The invention generally concerns compositions and methods for genetic vaccination with amyloid beta (Aβ) protein. Such vaccines may provide effective treatment for neurodegenerative disease such as Alzheimer's disease. Vaccination methods are can be used to induce a Th2 type immune response directed to Aβ. This immune response id shown to substantially reduce Aβ concentration and Aβ plaque size in an Alzheimer's model system.