Inventors:
George Weiner - Iowa City IA
Roger Gingrich - Iowa City IA
Brian K. Link - Carlville IA
J. Yun Tso - Menlo Park CA
Assignee:
Protein Design Labs, Inc. - Fremont CA
International Classification:
A61K 39395, C12P 2104, C12P 2108, C07K 1600
Abstract:
The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.