Inventors:
Roger Wagner - Stanford CA, US
Raymond Tabibiazar - Stanford CA, US
Thomas Quertermous - Stanford CA, US
International Classification:
C12Q 1/68, G01N 33/53, C12M 1/34
US Classification:
435006000, 435007100, 435287200
Abstract:
The present invention identifies genes whose gene products are differentially expressed pressure overload of the heart. The invention provides methods for diagnosing or assessing an individual's susceptibility to heart failure from many etiologies, as well as the presence and severity of hypertrophy, chamber enlargement, or systolic heat failure. Also provided are therapeutic methods for treating a heart patient or methods for prophylactically treating an individual susceptible to heart failure. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered a heart attack or are at risk of heart failure.