Inventors:
Robert L. Zerbe - Ann Arbor MI, US
Alexander Bridges - Saline MI, US
Risto Lammintausta - Turku, FI
Rochelle Hanley - Ann Arbor MI, US
Stuart Dombey - Ann Arbor MI, US
Assignee:
QUATRX PHARMACEUTICALS COMPANY - Ann Arbor MI
International Classification:
A61K 31/53, A61K 31/085, A61K 31/135, A61P 15/00, A61K 31/4985, A61K 31/496
US Classification:
514243, 514720, 514648, 51425216, 514250
Abstract:
A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level. Fispemifene may be used in combination with a PDE-5 inhibitor in individuals who have failed to respond sufficiently to conventional ED treatment. Methods are also disclosed of treating ED by administering clomifene, enclomifene, ospemifene, toremifene and mixtures thereof in combination with a PDE-5 inhibitor.